Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676282 | 0.85 | MAPT (0.45) | KDRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL674851 | 0.84 | MAP2 (0.49) | MAP2JAK2CCKBRGRIN2DGRIN3B | |
| SCHEMBL674860 | 0.84 | SMN1; SMN2 (0.38) | MAP2JAK2CCKBRGRIN2DGRIN3B | |
| SCHEMBL674892 | 0.81 | KDM4E (0.48) | MAP2CCKBRERBB2PTK6GABRP | |
| SCHEMBL675814 | 0.81 | GABRP (0.44) | CCKBRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11860308 | 0.80 | KDR (0.46) | CHEK1KDRKMT2AMEN1RAB9A | |
| SCHEMBL676824 | 0.79 | KDM4E (0.42) | CCKBRCHEK1KDRGRIN2DGRIN3B | |
| SCHEMBL3669225 | 0.78 | AURKA (0.47) | CHEK1KDRERBB2PTK6 | |
| SCHEMBL675229 | 0.77 | ERBB2 (0.53) | MAP2CCKBRCHEK1ERBB2PTK6 | |
| SCHEMBL15873503 | 0.76 | CHUK (0.54) | MAP2JAK2CHEK1KDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |