Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 7/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2121617 | 0.87 | NOTUM (0.45) | NOTUMARHTR2CHTR2B | |
| SCHEMBL23491420 | 0.81 | UCHL1 (0.37) | KDM1AALDH1A1 | |
| SCHEMBL2824001 | 0.76 | AKR1C3 (0.38) | NOTUMDRD4 | |
| SCHEMBL3664397 | 0.75 | NOTUM (0.36) | NOTUMARHTR2CHTR2BDRD4 | |
| SCHEMBL2121976 | 0.75 | NOTUM (0.36) | NOTUMARSSTR4 | |
| SCHEMBL3660735 | 0.74 | — | — | |
| SCHEMBL2122061 | 0.70 | UCHL1 (0.42) | NOTUMDRD4ALDH1A1 | |
| SCHEMBL2123452 | 0.69 | NOTUM (0.43) | NOTUMARCCR2ADRA1AALDH1A1 | |
| SCHEMBL20300222 | 0.69 | ESR2 (0.41) | DRD4 | |
| SCHEMBL2121418 | 0.68 | CAMK2A (0.40) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222670-A1 | OXADIAZOLE DERIVATIVES FOR USE AS S1P1 AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | Glaxo Group Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009080729-A1 | OXADIAZOLE DERIVATIVES FOR USE AS S1P1 AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |