Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL159499 | 1.00 | — | — | |
| Propylene Glycol SCHEMBL156298 | 1.00 | — | — | |
| Propylene Glycol SCHEMBL1985568 | 1.00 | — | — | |
| Propylene Glycol SCHEMBL170557 | 1.00 | — | — | |
| Propylene Glycol SCHEMBL10332456 | 1.00 | TDP1 (0.91) | — | |
| Propylene Glycol SCHEMBL5051858 | 1.00 | TDP1 (0.91) | — | |
| Propylene Glycol SCHEMBL1988316 | 0.96 | — | — | |
| Propylene Glycol SCHEMBL29058944 | 0.96 | — | — | |
| Propylene Glycol SCHEMBL11140327 | 0.96 | — | — | |
| Propylene Glycol SCHEMBL28330090 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4245299-A2 | Pharmaceutical formulations containing dapagliflozin propylene glycol hydrate | Astrazeneca AB (SE) | 2023-09-20 | — | — | EP | disclosed |
| EP-2508188-B1 | Pharmaceutical formulations containing dapagliflozin propylene glycol hydrate | ASTRAZENECA AB (SE) | 2023-05-10 | — | — | EP | disclosed |
| WO-2022067724-A1 | SGLT-2 INHIBITOR SARCOSINE CO-CRYSTAL, PREPARATION METHOD THEREFOR AND USE THEREOF | 北京睿创康泰医药研究院有限公司 | 2022-04-07 | — | — | WO | disclosed |
| EP-2139494-B1 | PHARMACEUTICAL FORMULATIONS CONTAINING DAPAGLIFLOZIN PROPYLENE GLYCOL HYDRATE | ASTRAZENECA AB (SE) | 2020-03-11 | — | — | EP | disclosed |
| US-9198925-B2 | Pharmaceutical formulations containing an SGLT2 inhibitor | ASTRAZENECA AB (SE) | 2015-12-01 | — | — | US | disclosed |
| US-20140243262-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING AN SGLT2 INHIBITOR | ASTRAZENECA AB (SE) | 2014-08-28 | — | — | US | disclosed |
| US-8361972-B2 | Pharmaceutical formulations containing an SGLT2 inhibitor | BRISTOL MYERS-SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120263786-A1 | Pharmaceutical Formulations Containing an SGLT2 Inhibitor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-10-18 | — | — | US | disclosed |
| EP-2508188-A1 | Pharmaceutical formulations containing dapagliflozin propylene glycol hydrate | Bristol-Myers Squibb Company (US) | 2012-10-10 | — | — | EP | disclosed |
| US-8221786-B2 | Pharmaceutical formulations containing an SGLT2 inhibitor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-07-17 | — | — | US | disclosed |
| US-7851502-B2 | Dapagliflozin propylene glycol hydrate; diabetes; immediate release; sodium dependent glucose transporter (SGLT2) inhibitor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-14 | — | — | US | disclosed |
| EP-2139494-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING DAPAGLIFLOZIN PROPYLENE GLYCOL HYDRATE | Bristol-Myers Squibb Company (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116179-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING DAPAGLIFLOZIN PROPYLENE GLYCOL HYDRATE | BRISTOL-MYERS SQUIBB (US) | 2008-09-25 | — | — | WO | disclosed |
| US-20080234366-A1 | Dapagliflozin propylene glycol hydrate; diabetes; immediate release; sodium dependent glucose transporter (SGLT2) inhibitor | BRISTOL-MYERS SQUIBB (US) | 2008-09-25 | — | — | US | disclosed |
| EP-1251833-A1 | GELLAN GUM DIPPED PRODUCTS | MONSANTO COMPANY, Pharmaceutical Ingredients (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001056550-A1 | GELLAN GUM DIPPED PRODUCTS | MONSANTO COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |