Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616195 | 0.91 | MEN1 (0.45) | CYP19A1MEN1KMT2AUSP2HTR2C | |
| SCHEMBL15874851 | 0.88 | CYP19A1 (0.47) | CYP19A1MEN1KMT2AUSP2TNKS | |
| SCHEMBL1616886 | 0.88 | CYP19A1 (0.47) | CYP19A1MEN1KMT2AUSP2TNKS | |
| SCHEMBL30496207 | 0.88 | CYP19A1 (0.47) | CYP19A1MEN1KMT2AUSP2TNKS | |
| SCHEMBL512007 | 0.84 | CYP19A1 (0.48) | CYP19A1MEN1KMT2AUSP2HTR2C | |
| SCHEMBL3662535 | 0.73 | MAOA (0.33) | MEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL19993899 | 0.72 | HCRTR1 (0.40) | MEN1KMT2AUSP2HCRTR1HCRTR2 | |
| SCHEMBL17185892 | 0.70 | TP53 (0.43) | HTR2CCA1CA2CA4CA6 | |
| SCHEMBL4918535 | 0.69 | TP53 (0.46) | MEN1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL1616342 | 0.69 | TP53 (0.41) | HTR2CALDH1A1CA1CA2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231629-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009087127-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-16 | — | — | WO | disclosed |