Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3020640 | 0.96 | KDM1A (0.36) | KDM1A | |
| SCHEMBL19126994 | 0.81 | KDM1A (0.36) | KDM1A | |
| SCHEMBL15897036 | 0.81 | BACE1 (0.37) | KDM1A | |
| SCHEMBL7570951 | 0.81 | KDM1A (0.50) | KDM1A | |
| SCHEMBL3899441 | 0.78 | MEN1 (0.43) | KDM1A | |
| SCHEMBL6568601 | 0.76 | KDM1A (0.41) | KDM1A | |
| SCHEMBL3905338 | 0.76 | OPRM1 (0.33) | KDM1A | |
| SCHEMBL21505445 | 0.74 | BAZ2B (0.43) | — | |
| SCHEMBL768934 | 0.74 | BACE1 (0.43) | KDM1A | |
| SCHEMBL769008 | 0.74 | KDM1A (0.43) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |