Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 8/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657821 | 0.87 | PLK1 (0.39) | PLK1KDRULK1ULK2PSEN1 | |
| SCHEMBL3665907 | 0.87 | PLK1 (0.39) | PLK1KDRULK1ULK2PSEN1 | |
| SCHEMBL3663912 | 0.87 | PSEN1 (0.40) | PLK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3664634 | 0.86 | PSEN1 (0.39) | PLK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3661161 | 0.86 | PLK1 (0.38) | PLK1KDRULK1ULK2PSEN1 | |
| SCHEMBL3660797 | 0.84 | PLK1 (0.38) | PLK1KDRULK1ULK2PSEN1 | |
| SCHEMBL3663840 | 0.84 | PSEN1 (0.50) | PLK1KDRPSEN1PSEN2APH1B | |
| SCHEMBL3661496 | 0.84 | PSEN1 (0.40) | PLK1KDRULK1PSEN1PSEN2 | |
| SCHEMBL3662766 | 0.83 | PKMYT1 (0.39) | PLK1KDRPSEN1PSEN2APH1B | |
| SCHEMBL3659216 | 0.83 | PSEN1 (0.42) | PLK1KDRPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231629-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009087127-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-16 | — | — | WO | disclosed |