Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3012364 | 0.78 | ALDH1A1 (0.52) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL12545566 | 0.76 | MEN1 (0.51) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL25060427 | 0.75 | KDM4E (0.60) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL13522910 | 0.74 | MEN1 (0.51) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL3020584 | 0.74 | KMT2A (0.48) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL30161844 | 0.73 | ALDH1A1 (0.76) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL2088159 | 0.73 | ALDH1A1 (0.76) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL24462096 | 0.73 | NPC1 (0.56) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL25068629 | 0.73 | KDM4E (0.62) | MEN1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL24556005 | 0.72 | ALDH1A1 (0.57) | MEN1ALDH1A1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522394-B1 | Substituted phosphonates and their use decreasing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2016-12-28 | — | — | EP | disclosed |
| EP-2522394-A2 | Substituted phosphonates and their use decreasing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-11-14 | — | — | EP | disclosed |
| EP-2152368-A1 | SUBSTITUTED PHOSPHONATES AND THEIR USE IN DECREASING AMYLOID AGGREGATES | Queen Mary and Westfield College (GB) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008135743-A1 | SUBSTITUTED PHOSPHONATES AND THEIR USE IN DECREASING AMYLOID AGGREGATES | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-11-13 | — | — | WO | disclosed |