Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095382 | 0.80 | HRH3 (0.44) | NR1H2NR1H3MAPTKMT2ANPSR1 | |
| SCHEMBL1095813 | 0.80 | HRH3 (0.44) | NR1H2NR1H3MAPTKMT2ANPSR1 | |
| SCHEMBL1095383 | 0.80 | HRH3 (0.44) | NR1H2NR1H3MAPTKMT2ANPSR1 | |
| SCHEMBL3665269 | 0.76 | RAB9A (0.47) | NR1H2NR1H3MAPTNPC1RAB9A | |
| SCHEMBL1094234 | 0.68 | HRH3 (0.50) | MAPTKMT2ANPSR1HRH3KCNH2 | |
| SCHEMBL1096234 | 0.68 | HRH3 (0.50) | MAPTKMT2ANPSR1HRH3KCNH2 | |
| SCHEMBL1094232 | 0.68 | HRH3 (0.50) | MAPTKMT2ANPSR1HRH3KCNH2 | |
| SCHEMBL1094449 | 0.67 | HRH3 (0.45) | NR1H2NR1H3MAPTKMT2ANPSR1 | |
| SCHEMBL1094450 | 0.67 | HRH3 (0.45) | NR1H2NR1H3MAPTKMT2ANPSR1 | |
| SCHEMBL1095586 | 0.66 | HRH3 (0.65) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2237779-A1 | BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND METHODS OF USE | Abbott Laboratories (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009085945-A1 | BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | WO | disclosed |