SCHEMBL3665826

SCHEMBL3665826

Cc1ccc(Br)c(-c2cc(-c3cccnc3)cc(O)n2)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.44
CYP19A1 P11511 2/20 0.42
NPC1 O15118 2/20 0.40
KDM4E B2RXH2 1/20 0.40
RAB9A P51151 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CYP3A4 P08684 3/20 0.40
CYP11B1 P15538 2/20 0.40
CYP11B2 P19099 2/20 0.40
CYP2E1 P05181 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2B6 P20813 2/20 0.40
NQO2 P16083 1/20 0.40
ADORA2A P29274 1/20 0.40
ADORA2B P29275 1/20 0.40
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
EGFR P00533 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3947748 0.71 CYP2A6 (0.53) CYP2A6CYP19A1NPC1KDM4ERAB9A
SCHEMBL21083089 0.71 CYP19A1 (0.59) CYP2A6CYP19A1NPC1KDM4ERAB9A
SCHEMBL19009235 0.70 CYP2A6 (0.81) CYP2A6CYP19A1CYP3A4CYP11B1CYP11B2
SCHEMBL12861647 0.70 CYP19A1 (0.66) CYP2A6CYP19A1KDM4ECYP3A4CYP11B1
SCHEMBL15984859 0.69 CYP2A6 (0.62) CYP2A6CYP19A1NPC1KDM4ERAB9A
SCHEMBL3658012 0.68 CYP2A6 (0.43) CYP2A6CYP11B1CYP11B2
SCHEMBL30060579 0.67 KDM4E (0.57) CYP2A6CYP19A1NPC1KDM4ERAB9A
SCHEMBL4631807 0.67 KDM4E (0.57) CYP2A6CYP19A1NPC1KDM4ERAB9A
SCHEMBL29907865 0.67 CYP19A1 (0.79) CYP2A6CYP19A1NPC1KDM4ERAB9A
SCHEMBL28912921 0.67 CYP19A1 (0.79) CYP2A6CYP19A1NPC1KDM4ERAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2242742-A2 ORGANIC COMPOUNDS Novartis AG (CH) 2010-10-27 EP disclosed
WO-2009087212-A2 PYRIDINE DERIVATIVES NOVARTIS AG (CH) 2009-07-16 WO disclosed