Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063246 | 0.98 | TSHR (0.59) | TSHRTAAR1CHRNA7MEN1GAA | |
| SCHEMBL7662585 | 0.82 | TSHR (0.54) | TSHRCHRNA7 | |
| SCHEMBL3400430 | 0.80 | TSHR (0.43) | TSHR | |
| SCHEMBL8014225 | 0.75 | PARP3 (0.46) | TSHRTAAR1CHRNA7ALDH1A1TDP1 | |
| SCHEMBL27879568 | 0.73 | KDM4E (0.35) | TSHRALDH1A1 | |
| SCHEMBL1218926 | 0.70 | GAA (0.41) | TSHRMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL11193476 | 0.70 | TSHR (0.51) | TSHRCHRNA7ALDH1A1TDP1 | |
| SCHEMBL11198053 | 0.70 | TSHR (0.51) | TSHRCHRNA7ALDH1A1TDP1 | |
| SCHEMBL11194889 | 0.70 | TSHR (0.51) | TSHRCHRNA7ALDH1A1TDP1 | |
| SCHEMBL30417082 | 0.69 | CHRNB4 (0.39) | MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015708-A | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC | 2011-04-13 | — | — | CN | claimed |
| CN-109689639-A | Spirolactams as ROCK inhibitor | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-102015708-A | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC | 2011-04-13 | — | — | CN | disclosed |
| EP-2240483-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089454-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |