Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3781387 | 0.87 | P2RX3 (0.65) | P2RX3P2RX2 | |
| SCHEMBL2275053 | 0.85 | P2RX3 (0.64) | P2RX3P2RX2 | |
| SCHEMBL357921 | 0.84 | P2RX3 (0.62) | P2RX3P2RX2 | |
| SCHEMBL4159057 | 0.83 | P2RX3 (0.65) | P2RX3P2RX2 | |
| SCHEMBL3719049 | 0.82 | P2RX3 (0.62) | P2RX3P2RX2 | |
| SCHEMBL4417922 | 0.82 | P2RX3 (0.73) | P2RX3P2RX2 | |
| SCHEMBL3795431 | 0.81 | P2RX3 (0.60) | P2RX3P2RX2 | |
| SCHEMBL3779297 | 0.81 | P2RX3 (0.60) | P2RX3P2RX2 | |
| SCHEMBL2276438 | 0.81 | P2RX3 (0.65) | P2RX3P2RX2 | |
| SCHEMBL3664569 | 0.81 | P2RX3 (0.43) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234981-B1 | NOVEL IMIDAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-03-30 | — | — | EP | disclosed |
| EP-2234981-B1 | NOVEL IMIDAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-03-30 | — | — | EP | disclosed |
| CN-101903355-B | Imidazole-substituted arylamides | HOFFMANN LA ROCHE | 2014-05-14 | — | — | CN | disclosed |
| US-7858654-B2 | Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2010-12-28 | — | — | US | disclosed |
| US-7858654-B2 | Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2010-12-28 | — | — | US | disclosed |
| US-7858654-B2 | Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2010-12-28 | — | — | US | disclosed |
| CN-101903355-A | Novel imidazole-substituted arylamides | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| EP-2234981-A1 | NOVEL IMIDAZOLE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| US-20090163499-A1 | Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC | 2009-06-25 | — | — | US | disclosed |
| US-20090163499-A1 | Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC | 2009-06-25 | — | — | US | disclosed |
| US-20090163499-A1 | Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC | 2009-06-25 | — | — | US | disclosed |
| WO-2009077365-A1 | NOVEL IMIDAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009077365-A1 | NOVEL IMIDAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163499-A1 | Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists | P2RX3, P2RX2, P2RX1 | P2RX3 1/4885P2RX2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.