SCHEMBL3666263

SCHEMBL3666263

NC(=O)C1CC(F)(F)CN1

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 1/20 0.38
GRM3 Q14832 1/20 0.38
CYP1A2 P05177 1/20 0.38
ALOX15 P16050 1/20 0.38
CTSC P53634 1/20 0.33
GLI1 P08151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3666260 1.00 GRM2 (0.38) GRM2GRM3CYP1A2ALOX15CTSC
SCHEMBL26101059 1.00 GRM2 (0.38) GRM2GRM3CYP1A2ALOX15CTSC
Hydrochloric Acid SCHEMBL1347345 0.98 GRM2 (0.37) GRM2GRM3CYP1A2ALOX15CTSC
Hydrochloric Acid SCHEMBL15776372 0.98 GRM2 (0.37) GRM2GRM3CYP1A2ALOX15CTSC
Hydrochloric Acid SCHEMBL6826204 0.98 GRM2 (0.37) GRM2GRM3CYP1A2ALOX15CTSC
Trifluoroacetic Acid SCHEMBL15129828 0.89 GRM2 (0.36) GRM2GRM3CYP1A2ALOX15CTSC
SCHEMBL24021079 0.80 GRM2 (0.34) GRM2GRM3CYP1A2ALOX15
SCHEMBL40622 0.80 CYP1A2 (0.53) GRM2GRM3CYP1A2ALOX15CTSC
SCHEMBL3145095 0.80 CYP1A2 (0.53) GRM2GRM3CYP1A2ALOX15CTSC
SCHEMBL40623 0.80 CYP1A2 (0.53) GRM2GRM3CYP1A2ALOX15CTSC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118084935-A Imidazolidinone compound as well as preparation method and application thereof 贝达药业股份有限公司 2024-05-28 CN claimed
US-20230053342-A1 IMIDAZOLIDINONE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF BETTA PHARMACEUTICALS CO., LTD (CN) 2023-02-23 US claimed
EP-4056575-A1 IMIDAZOLIDINONE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Betta Pharmaceuticals Co., Ltd (CN) 2022-09-14 EP claimed
CN-114599655-A Imidazolidinone compound and preparation method and application thereof 贝达药业股份有限公司 2022-06-07 CN claimed
EP-3515913-B1 AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES NOVARTIS AG (CH) 2022-05-11 EP claimed
EP-4590670-A1 PLATFORM AND SCAFFOLD FOR FAP TARGETING AGENTS Erasmus University Rotterdam Medical Center (NL) 2025-07-30 EP disclosed
WO-2025063849-A2 DIMERIC FAP TARGETING AGENTS ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) 2025-03-27 WO disclosed
US-20240382624-A1 FIBROBLAST ACTIVATION PROTEIN TARGETED DYES THEIR RELATED USES ON TARGET LABORATORIES INC (US) 2024-11-21 US disclosed
US-20240299590-A1 FIBROBLAST ACTIVATION PROTEIN TARGETED DYES THEIR RELATED USES ON TARGET LABORATORIES INC (US) 2024-09-12 US disclosed
CN-118084935-A Imidazolidinone compound as well as preparation method and application thereof 贝达药业股份有限公司 2024-05-28 CN disclosed
WO-2024063648-A1 Platform and scaffold for FAP targeting agents ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) 2024-03-28 WO disclosed
EP-4342890-A1 PLATFORM AND SCAFFOLD FOR FAP TARGETING AGENTS Erasmus University Rotterdam Medical Center (NL) 2024-03-27 EP disclosed
CN-102459165-A Anti-viral compounds ABBOTT LAB 2012-05-16 CN disclosed
EP-2240475-A1 THIAZOLE DERIVATIVES USED AS PI 3 KINASE INHIBITORS Novartis AG (CH) 2010-10-20 EP disclosed
EP-1773796-B1 OXOPIPERIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2010-03-03 EP disclosed
WO-2009080694-A1 THIAZOLE DERIVATIVES USED AS PI 3 KINASE INHIBITORS NOVARTIS AG (CH) 2009-07-02 WO disclosed
US-20090163469-A1 Organic Compounds NOVARTIS AG 2009-06-25 US disclosed
EP-1919864-A2 FAP INHIBITORS Ferring B.V. (NL) 2008-05-14 EP disclosed
WO-2007085895-A2 FAP INHIBITORS FERRING B.V. (US) 2007-08-02 WO disclosed
WO-2004099185-A1 2-CYANOPYRROLIDINE DERIVATIVES AND THEIR USE AS DPP-IV INHIBITORS FUJISAWA PHARMACEUTICAL CO. LTD. (JP) 2004-11-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240382624-A1 FIBROBLAST ACTIVATION PROTEIN TARGETED DYES THEIR RELATED USES FAP, FIBP, IK GRM2 4864/4885GRM3 4866/4885CYP1A2 3459/4885
US-20230053342-A1 IMIDAZOLIDINONE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF WEE1, SLC5A11, CYP51A1 GRM2 4382/4885GRM3 4522/4885CYP1A2 655/4885
US-20240299590-A1 FIBROBLAST ACTIVATION PROTEIN TARGETED DYES THEIR RELATED USES FAP, FIBP, IK GRM2 4864/4885GRM3 4866/4885CYP1A2 3459/4885
US-20090163469-A1 Organic Compounds PIK3C3, PIK3CA, PIK3CD GRM2 3604/4885GRM3 2692/4885CYP1A2 618/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.