Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 8/20 | 0.72 |
| ▸ | PDE1A | P54750 | 6/20 | 0.72 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.72 |
| ▸ | PDE2A | O00408 | 6/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE8A | O60658 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713156 | 0.93 | PDE1B (0.71) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL194641 | 0.91 | PDE1B (0.73) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL3091517 | 0.91 | PDE1B (0.72) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL17507919 | 0.89 | PDE1B (0.70) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL3087225 | 0.88 | PDE1B (0.69) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL3094574 | 0.88 | PDE1B (0.76) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL194205 | 0.88 | PDE1B (0.69) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL17507915 | 0.87 | PDE1B (0.68) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL17539953 | 0.87 | PDE1B (0.68) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL194194 | 0.87 | PDE1B (0.68) | PDE1BPDE1APDE1CPDE2APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240028-B1 | Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical | INTRA CELLULAR THERAPIES INC (US) | 2016-07-20 | — | — | EP | disclosed |
| US-20150197524-A1 | ORGANIC COMPOUNDS | LI PENG (US) | 2015-07-16 | — | — | US | disclosed |
| US-8846693-B2 | Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones | INTRA-CELLULAR THERAPIES, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| EP-2240028-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009073210-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197524-A1 | ORGANIC COMPOUNDS | OPRD1, HTR1D, DRD1 | PDE1B 115/4885PDE1A 77/4885PDE1C 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.