Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.67 |
| ▸ | GSK3B | P49841 | 12/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.67 |
| ▸ | JAK2 | O60674 | 9/20 | 0.67 |
| ▸ | PRKACA | P17612 | 8/20 | 0.57 |
| ▸ | CDK2 | P24941 | 8/20 | 0.57 |
| ▸ | CDC7 | O00311 | 8/20 | 0.57 |
| ▸ | AURKA | O14965 | 7/20 | 0.57 |
| ▸ | CDK1 | P06493 | 7/20 | 0.57 |
| ▸ | GSK3A | P49840 | 7/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.57 |
| ▸ | CDC42BPA | Q5VT25 | 7/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.57 |
| ▸ | MARK3 | P27448 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.57 |
| ▸ | AKT1 | P31749 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667241 | 0.85 | CDC7 (0.75) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3667957 | 0.82 | ROCK2 (1.00) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3668436 | 0.79 | CDC7 (0.72) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3667213 | 0.77 | GSK3B (0.79) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3665013 | 0.76 | JAK2 (1.00) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3666000 | 0.74 | CDC7 (0.71) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3665661 | 0.73 | GSK3B (1.00) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3673840 | 0.73 | CDC7 (0.80) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3666406 | 0.72 | ROCK2 (0.71) | ROCK2GSK3BAURKBJAK2PRKACA | |
| SCHEMBL3671481 | 0.72 | ROCK2 (0.71) | ROCK2GSK3BAURKBJAK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | claimed |