Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.66 |
| ▸ | GSK3B | P49841 | 10/20 | 0.66 |
| ▸ | CDC7 | O00311 | 10/20 | 0.66 |
| ▸ | PRKACA | P17612 | 9/20 | 0.66 |
| ▸ | CDK2 | P24941 | 9/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.66 |
| ▸ | CDK1 | P06493 | 7/20 | 0.66 |
| ▸ | GSK3A | P49840 | 7/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.66 |
| ▸ | CDC42BPA | Q5VT25 | 7/20 | 0.66 |
| ▸ | AURKA | O14965 | 6/20 | 0.66 |
| ▸ | AKT1 | P31749 | 6/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.66 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.66 |
| ▸ | SGK2 | Q9HBY8 | 6/20 | 0.66 |
| ▸ | PRKCG | P05129 | 6/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287555 | 0.89 | ROCK2 (0.59) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL3667164 | 0.81 | CDC7 (0.59) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL3665661 | 0.79 | GSK3B (1.00) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL3668504 | 0.78 | GSK3B (0.75) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL3667213 | 0.78 | GSK3B (0.79) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL3670360 | 0.77 | GSK3B (0.84) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL3666406 | 0.77 | ROCK2 (0.71) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL3668848 | 0.76 | GSK3B (1.00) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL27810082 | 0.76 | GSK3B (0.71) | ROCK2ROCK1GSK3BCDC7PRKACA | |
| SCHEMBL3673480 | 0.76 | ROCK2 (0.82) | ROCK2ROCK1GSK3BCDC7PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |