Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.66 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | WNT3A | P56704 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL601208 | 0.89 | DGAT1 (0.76) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL600725 | 0.89 | DGAT1 (0.76) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL600726 | 0.89 | DGAT1 (0.76) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL3669325 | 0.88 | DGAT1 (0.52) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL3668678 | 0.86 | DGAT1 (0.64) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL3669423 | 0.85 | DGAT1 (0.82) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| Bicarbonate SCHEMBL15656218 | 0.84 | DGAT1 (0.80) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| Bicarbonate SCHEMBL15655183 | 0.80 | DGAT1 (0.61) | NPC1RAB9AMEN1KMT2ADGAT1 | |
| Bicarbonate SCHEMBL15656215 | 0.80 | DGAT1 (0.85) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL601428 | 0.79 | DGAT1 (0.65) | NPC1RAB9AMEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | claimed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | claimed |
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | disclosed |