Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 11/20 | 0.72 |
| ▸ | F2 | P00734 | 4/20 | 0.70 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.70 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.70 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.70 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.70 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | KLK1 | P06870 | 1/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3875680 | 0.88 | PRSS1 (0.84) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL13716049 | 0.84 | PRSS1 (0.66) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL5524345 | 0.84 | PRSS1 (1.00) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL17515720 | 0.82 | PRSS1 (0.75) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL22182052 | 0.81 | PRSS1 (0.49) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL10694847 | 0.81 | SMN1; SMN2 (0.54) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL20001656 | 0.80 | PRSS1 (0.66) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL12348324 | 0.79 | PRSS1 (0.70) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6339014 | 0.79 | MAPT (0.44) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL12461511 | 0.79 | PRSS1 (0.82) | PRSS1F2PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170846-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | Intervet International BV (NL) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009005646-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| US-7459442-B2 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof | SCHERING CORPORATION (US) | 2008-12-02 | — | — | US | disclosed |
| WO-2007123949-A2 | CANNABINOID RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2007-11-01 | — | — | WO | disclosed |
| EP-1819684-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006060461-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2006-06-08 | — | — | WO | disclosed |