Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666556 | 0.88 | BTK (0.60) | BTKKDM4ERAB9A | |
| SCHEMBL1724788 | 0.85 | BTK (0.64) | BTKKDM4ERAB9ASRCCLK2 | |
| SCHEMBL3668669 | 0.83 | BTK (0.61) | BTKKDM4ERAB9ASRCTYK2 | |
| SCHEMBL1725599 | 0.77 | BTK (0.80) | BTKCLK2 | |
| SCHEMBL3215296 | 0.76 | BTK (0.68) | BTKCLK2 | |
| SCHEMBL3674873 | 0.76 | BTK (0.58) | BTKKDM4ERAB9ACLK2 | |
| SCHEMBL3218407 | 0.76 | BTK (0.73) | BTKCLK2 | |
| SCHEMBL13139723 | 0.75 | BTK (0.68) | BTKCLK2 | |
| SCHEMBL1725256 | 0.75 | BTK (0.81) | BTKCLK2 | |
| SCHEMBL3212532 | 0.74 | BTK (0.72) | BTKCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242749-A1 | NOVEL PYRIDINONES AND PYRIDAZINONES | F. Hoffmann-La Roche AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009098144-A1 | NOVEL PYRIDINONES AND PYRIDAZINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | WO | disclosed |