Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724590 | 0.85 | BTK (0.79) | BTKCLK2 | |
| SCHEMBL3666556 | 0.83 | BTK (0.60) | BTKKDM4ERAB9A | |
| SCHEMBL3654050 | 0.80 | BTK (0.50) | BTKKDM4ERAB9ACLK2 | |
| SCHEMBL3671891 | 0.80 | BTK (0.56) | BTK | |
| SCHEMBL3665173 | 0.79 | BTK (0.51) | BTKKDM4ERAB9ACLK2 | |
| SCHEMBL3211683 | 0.77 | BTK (0.80) | BTKCLK2 | |
| SCHEMBL13178747 | 0.77 | BTK (0.80) | BTKCLK2 | |
| SCHEMBL16013147 | 0.77 | BTK (0.47) | BTKKDM4ERAB9ACLK2 | |
| SCHEMBL3668896 | 0.76 | BTK (0.52) | BTKKDM4ERAB9ACLK2 | |
| SCHEMBL1724202 | 0.76 | BTK (0.84) | BTKCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242749-A1 | NOVEL PYRIDINONES AND PYRIDAZINONES | F. Hoffmann-La Roche AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009098144-A1 | NOVEL PYRIDINONES AND PYRIDAZINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | WO | disclosed |