Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 20/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668946 | 0.90 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL4887773 | 0.88 | AGTR1 (0.67) | AGTR1AGTR2 | |
| SCHEMBL3634588 | 0.86 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL3634591 | 0.86 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL4881716 | 0.81 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL3642042 | 0.80 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL4887271 | 0.79 | AGTR1 (0.74) | AGTR1AGTR2 | |
| SCHEMBL4887261 | 0.79 | AGTR1 (0.74) | AGTR1AGTR2 | |
| SCHEMBL3638495 | 0.79 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL3639727 | 0.79 | AGTR1 (0.50) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162442-A1 | DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008153857-A1 | DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-12-18 | — | — | WO | disclosed |