Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 12/20 | 0.70 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666067 | 0.87 | CRHR1 (0.69) | CRHR1MAOBADORA1ADORA2A | |
| SCHEMBL3664462 | 0.84 | CRHR1 (0.68) | CRHR1MAOBADORA1ADORA2A | |
| SCHEMBL3746120 | 0.84 | CRHR1 (0.64) | CRHR1MAOB | |
| SCHEMBL3666714 | 0.83 | CRHR1 (0.67) | CRHR1MAOBADORA1ADORA2A | |
| SCHEMBL3668349 | 0.83 | CRHR1 (0.64) | CRHR1MAOBADORA1 | |
| SCHEMBL3759020 | 0.83 | CRHR1 (1.00) | CRHR1MAOBADORA1 | |
| SCHEMBL3750857 | 0.83 | CRHR1 (0.69) | CRHR1MAOBADORA1ADORA2A | |
| SCHEMBL3667990 | 0.82 | CRHR1 (0.63) | CRHR1MAOB | |
| SCHEMBL3748617 | 0.81 | CRHR1 (0.62) | CRHR1MAOB | |
| SCHEMBL3669215 | 0.81 | CRHR1 (0.72) | CRHR1MAOBADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |