Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16162068 | 0.85 | CRHR1 (0.61) | CRHR1KDM4EALDH1A1LMNAPDE2A | |
| SCHEMBL3753893 | 0.84 | CRHR1 (0.62) | CRHR1KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3748467 | 0.80 | CRHR1 (0.59) | CRHR1KDM4EALDH1A1LMNAPDE2A | |
| SCHEMBL3750699 | 0.79 | CRHR1 (0.60) | CRHR1KDM4EALDH1A1LMNATSHR | |
| SCHEMBL16162066 | 0.78 | CRHR1 (0.63) | CRHR1KDM4EALDH1A1LMNAPDE2A | |
| SCHEMBL3724782 | 0.78 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL3751391 | 0.77 | CRHR1 (0.64) | CRHR1KDM4EALDH1A1LMNAPDE2A | |
| SCHEMBL16162117 | 0.77 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL3746635 | 0.77 | CRHR1 (0.62) | CRHR1KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL3753972 | 0.77 | CRHR1 (0.57) | CRHR1KDM4EALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | claimed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | claimed |