Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.65 |
| ▸ | KHK | P50053 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 15/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 14/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651303 | 0.94 | TRPV4 (0.71) | TRPV4KHKCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL9489932 | 0.91 | TRPV4 (0.61) | TRPV4KHKCYP11B2CYP11B1 | |
| SCHEMBL2783854 | 0.88 | TRPV4 (0.56) | TRPV4KHKCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL20444058 | 0.83 | TRPV4 (0.54) | TRPV4KHKCYP11B2CYP11B1 | |
| SCHEMBL20444106 | 0.83 | TRPV4 (0.60) | TRPV4KHKCYP11B2CYP11B1 | |
| SCHEMBL29242731 | 0.81 | TRPV4 (0.58) | TRPV4KHKCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL20444104 | 0.80 | TRPV4 (0.50) | TRPV4KHKCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL23830843 | 0.79 | TRPV4 (0.50) | TRPV4 | |
| SCHEMBL934418 | 0.79 | TRPV4 (0.50) | TRPV4KHKCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL10947192 | 0.79 | TRPV4 (0.56) | TRPV4KHKCYP11B2CYP11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 588 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774786-B1 | METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE | BAYER AG (DE) | 2024-12-25 | — | — | EP | claimed |
| CN-112236426-B | Process for preparing 2,4, 5-trisubstituted 1,2, 4-triazolones | 拜耳股份有限公司 | 2024-07-05 | — | — | CN | claimed |
| CN-118126051-A | Polymorphic substance of mutant BRAF degradation agent and preparation method thereof | C4医药公司 | 2024-06-04 | — | — | CN | claimed |
| EP-3898595-B1 | PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS | MERCK SHARP & DOHME LLC (US) | 2024-05-01 | — | — | EP | claimed |
| CN-117466729-A | Synthesis method of 2,4, 5-trifluoro phenylacetic acid | 山东国邦药业有限公司 | 2024-01-30 | — | — | CN | claimed |
| US-11365179-B2 | Method for the preparation of a 2,4,5-trisubstituted 1,2,4-triazolone | BAYER AKTIENGESELLSCHAFT (DE) | 2022-06-21 | — | — | US | claimed |
| EP-3774786-A1 | METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE | Bayer Aktiengesellschaft (DE) | 2021-02-17 | — | — | EP | claimed |
| US-20210032212-A1 | METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE | BAYER AKTIENGESELLSCHAFT (DE) | 2021-02-04 | — | — | US | claimed |
| CN-112236426-A | Process for preparing 2,4, 5-trisubstituted 1,2, 4-triazolones | 拜耳股份有限公司 | 2021-01-15 | — | — | CN | claimed |
| WO-2019197239-A1 | METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE | BAYER AKTIENGESELLSCHAFT (DE) | 2019-10-17 | — | — | WO | claimed |
| CN-102617570-A | Preparation method of 1,2-dihydroisoquinoline compound of pyrazole ring | UNIV FUDAN | 2012-08-01 | — | — | CN | claimed |
| US-6399807-B1 | REACTING 2,4,5-TRIFLUOROANILINE WITH NITROSATING AGENT IN DILUENT | BAYER AKTIEGESELLSCHAFT (DE) | 2002-06-04 | — | — | US | claimed |
| US-6075160-A | 4-cyano-2,5-difluoroaniline preparation process | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-13 | — | — | US | claimed |
| EP-0854859-B1 | 4-CYANO-2,5-DIFLUORANILINE PREPARATION PROCESS | BAYER AG (DE) | 2000-05-24 | — | — | EP | claimed |
| EP-0994849-A1 | METHOD FOR PRODUCTION OF 2,4,5-TRIFLUOROBENZONITRILE | BAYER AG (DE) | 2000-04-26 | — | — | EP | claimed |
| WO-1999001425-A1 | METHOD FOR PRODUCTION OF 2,4,5-TRIFLUOROBENZONITRILE | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-14 | — | — | WO | claimed |
| EP-0557949-B1 | Process for the preparation of 2,4,5 trifluorobenzonitrile | CLARIANT GMBH (DE) | 1998-12-16 | — | — | EP | claimed |
| EP-0854859-A1 | 4-CYANO-2,5-DIFLUORANILINE PREPARATION PROCESS | BAYER AG (DE) | 1998-07-29 | — | — | EP | claimed |
| WO-1997008136-A1 | 4-CYANO-2,5-DIFLUORANILINE PREPARATION PROCESS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-03-06 | — | — | WO | claimed |
| EP-0557949-A2 | Process for the preparation of 2,4,5 trifluorobenzonitrile | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-01 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032212-A1 | METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE | TES, CYP51A1, CYP4B1 | TRPV4 1840/4885KHK 1703/4885CYP11B2 17/4885 |
| US-11365179-B2 | Method for the preparation of a 2,4,5-trisubstituted 1,2,4-triazolone | TES, CYP51A1, CYP4B1 | TRPV4 1840/4885KHK 1703/4885CYP11B2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.