Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840041 | 0.94 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL840040 | 0.94 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL8823795 | 0.79 | DRD2 (0.56) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL4830434 | 0.78 | DRD2 (0.51) | DRD2 | |
| SCHEMBL5759457 | 0.78 | DRD2 (0.51) | DRD2 | |
| SCHEMBL4838334 | 0.78 | DRD2 (0.51) | DRD2 | |
| SCHEMBL8823690 | 0.78 | DRD2 (0.59) | DRD2DRD3HTR1D | |
| SCHEMBL8823682 | 0.78 | DRD2 (0.57) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL8823833 | 0.78 | DRD2 (0.59) | DRD2DRD3HTR1D | |
| SCHEMBL7651778 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |