SCHEMBL3670117

SCHEMBL3670117

CC(N)(N)c1c(Cl)ccc2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.50
ALDH1A1 P00352 5/20 0.43
HSD17B10 Q99714 4/20 0.43
TSHR P16473 3/20 0.43
CYP1A2 P05177 3/20 0.43
HPGD P15428 2/20 0.43
CYP3A4 P08684 2/20 0.43
KEAP1 Q14145 1/20 0.43
TDP1 Q9NUW8 1/20 0.41
MAPT P10636 3/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ITGB2 P05107 1/20 0.38
ICAM1 P05362 1/20 0.38
ITGAL P20701 1/20 0.38
HPRT1 P00492 2/20 0.38
PAX8 Q06710 1/20 0.36
HIF1A Q16665 1/20 0.35
CYP1B1 Q16678 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3668884 0.77 ALDH1A1 (0.43) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL3670399 0.77 ALDH1A1 (0.43) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL3704184 0.76 CYP2A6 (0.54) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL3670120 0.73 CYP2A6 (0.50) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL4078235 0.73 CYP2A6 (0.60) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL31499474 0.73 CYP2A6 (0.60) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL10425804 0.72 ALDH1A1 (0.52) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL9138639 0.71 HSD17B10 (0.42) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL8388759 0.69 PTPN22 (0.50) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2
SCHEMBL3891844 0.69 CYP2A6 (0.60) CYP2A6ALDH1A1HSD17B10TSHRCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1426392-B1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL CO (JP) 2010-02-24 EP disclosed
US-6960640-B2 Composition for optical material MITSUBISHI GAS CHEMICAL CO., LTD. (JP) 2005-11-01 US disclosed
US-20040147708-A1 Composition for optical material MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-07-29 US disclosed
EP-1426392-A1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-06-09 EP disclosed