SCHEMBL3670147

SCHEMBL3670147

CN1CCN(C(C(=O)N(N)c2cc(Cl)cc(Cl)c2)c2ccc3c(c2)CCO3)CC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OGA O60502 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
ACACB O00763 2/20 0.39
CCR3 P51677 2/20 0.38
CXCR3 P49682 6/20 0.37
FABP4 P15090 1/20 0.36
GCGR P47871 1/20 0.35
CHEK1 O14757 1/20 0.35
GPR183 P32249 1/20 0.35
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3640505 0.79 HDAC3 (0.50) OGAHDAC3HDAC4HDAC1HDAC7
SCHEMBL3638155 0.79 GHSR (0.45) OGAHDAC3HDAC4HDAC1HDAC7
SCHEMBL3635128 0.67 PTGS1 (0.57) OGATP53HPGD
SCHEMBL31287362 0.67 OGA (0.45) OGAHDAC3HDAC4HDAC1HDAC7
SCHEMBL3635412 0.67 GHSR (0.58) OGAHDAC3HDAC4HDAC1HDAC7
SCHEMBL3743236 0.65 GAA (0.55) OGATP53
SCHEMBL4441802 0.65 HDAC3 (0.59) OGAHDAC3HDAC4HDAC1HDAC7
SCHEMBL1915188 0.65 HDAC3 (0.58) OGAHDAC3HDAC4HDAC1HDAC7
Hydrochloric Acid SCHEMBL3637123 0.65 GAA (0.54) OGATP53
SCHEMBL15067694 0.64 HDAC3 (0.57) OGAHDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2167466-A1 N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR Glaxo Group Limited (GB) 2010-03-31 EP claimed
WO-2008148853-A1 N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR GLAXO GROUP LIMITED (GB) 2008-12-11 WO claimed
EP-2167466-A1 N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR Glaxo Group Limited (GB) 2010-03-31 EP disclosed
WO-2008148853-A1 N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR GLAXO GROUP LIMITED (GB) 2008-12-11 WO disclosed