⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367022 | 1.00 | — | — | |
| SCHEMBL2257240 | 1.00 | — | — | |
| SCHEMBL2554215 | 0.79 | CA2 (0.32) | — | |
| SCHEMBL2554205 | 0.79 | CA2 (0.32) | — | |
| SCHEMBL8471134 | 0.79 | CA2 (0.32) | — | |
| SCHEMBL2560550 | 0.79 | CA2 (0.32) | — | |
| SCHEMBL2560548 | 0.79 | CA2 (0.32) | — | |
| SCHEMBL18817839 | 0.79 | CA2 (0.32) | — | |
| SCHEMBL10777932 | 0.78 | — | — | |
| SCHEMBL14690105 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 807 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112225767-A | High-selectivity synthesis method of gemcitabine intermediate | 苏州华鑫医药科技有限公司 | 2021-01-15 | — | — | CN | claimed |
| CN-112079891-A | Preparation method of antitumor drug gemcitabine hydrochloride | 苏州华鑫医药科技有限公司 | 2020-12-15 | — | — | CN | claimed |
| CN-111732562-A | Preparation method of intermediate of antitumor drug gemcitabine hydrochloride | 苏州华鑫医药科技有限公司 | 2020-10-02 | — | — | CN | claimed |
| US-10633390-B2 | Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form | MSN LABORATORIES PRIVATE LIMITED (IN) | 2020-04-28 | — | — | US | claimed |
| CN-111040010-A | Synthetic method of sofosbuvir intermediate | 上海红蓝医药科技有限公司 | 2020-04-21 | — | — | CN | claimed |
| US-20180370982-A1 | PROCESS FOR THE PREPARATION OF [(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL] (2-METHYLPROPYL)AMINO]-2-HYDROXY-1-(PHENYLMETHYL)PROPYL]-CARBAMIC ACID (3R,3AS,6AR)HEXAHYDRO FURO[2,3-B]FURAN-3-YL ESTER AND ITS AMORPHOUS FORM | MSN LABORATORIES PRIVATE LIMITED (IN) | 2018-12-27 | — | — | US | claimed |
| CN-108307831-A | Golden silk willow engrafting method | 金华市野泉园艺技术有限公司 | 2018-07-24 | — | — | CN | claimed |
| CN-108243754-A | A kind of engrafting method of persimmon tree | 金华市飞凌生物科技有限公司 | 2018-07-06 | — | — | CN | claimed |
| CN-105669423-B | The novel synthesis of two kinds of enantiomters of 4- (4- (benzyloxy) phenyl) -2- hydroxybutyric acids | 江西科技师范大学 | 2018-06-29 | — | — | CN | claimed |
| CN-105859745-B | The method for selective synthesis of natural products Xylapyrroside A | 复旦大学 | 2018-05-25 | — | — | CN | claimed |
| US-20130096326-A1 | METHOD OF BIOBASED CHEMICAL PRODUCTION FROM CRUDE BIOGLYCERIN | THESIS CHEMISTRY, LLC (US) | 2013-04-18 | — | — | US | claimed |
| CN-101553485-B | Process for preparing nebivolol | ZACH SYSTEM SPA | 2013-02-06 | — | — | CN | claimed |
| US-8258323-B2 | Process for preparing nebivolol | ZACH SYSTEM S.P.A. (IT) | 2012-09-04 | — | — | US | claimed |
| US-20110201831-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2011-08-18 | — | — | US | claimed |
| US-7999124-B2 | Process for preparing nebivolol | ZACH SYSTEM S.P.A. (IT) | 2011-08-16 | — | — | US | claimed |
| EP-2099790-B1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM SPA (IT) | 2010-07-07 | — | — | EP | claimed |
| US-20100056813-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2010-03-04 | — | — | US | claimed |
| CN-101553485-A | Process for preparing nebivolol | ZACH SYSTEM SPA (IT) | 2009-10-07 | — | — | CN | claimed |
| EP-2099790-A2 | PROCESS FOR PREPARING NEBIVOLOL | ZaCh System S.p.A. (IT) | 2009-09-16 | — | — | EP | claimed |
| WO-2008064827-A2 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2008-06-05 | — | — | WO | claimed |