Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364154 | 0.90 | MAPT (0.39) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL366259 | 0.88 | ALDH1A1 (0.36) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL366083 | 0.87 | PSEN1 (0.38) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL365124 | 0.86 | FLT3 (0.35) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL367500 | 0.86 | PSEN1 (0.35) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL366403 | 0.86 | KDM4E (0.37) | ALDH1A1HSD17B10PSEN1PSEN2APH1B | |
| SCHEMBL367591 | 0.85 | PSEN1 (0.35) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL366563 | 0.85 | TSHR (0.40) | ALDH1A1HSD17B10PSEN1PSEN2APH1B | |
| SCHEMBL367127 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TP53HSD17B10GABRA1GABRG2 | |
| SCHEMBL364973 | 0.84 | KMT2A (0.42) | ALDH1A1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |