Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292554 | 0.91 | CDC7 (0.44) | CDC7MAP4K4PRKACAGSK3BCLK4 | |
| SCHEMBL3669940 | 0.77 | CYP19A1 (0.48) | CDC7MAP4K4PRKACAGSK3BCLK4 | |
| SCHEMBL4292592 | 0.75 | GRM2 (0.41) | CDC7MAP4K4PRKACAGSK3BCLK4 | |
| SCHEMBL3670826 | 0.74 | CDC7 (0.41) | CDC7MAP4K4PRKACAGSK3BCLK4 | |
| SCHEMBL4295553 | 0.73 | CDC7 (0.46) | CDC7MAP4K4PRKACAGSK3BCLK4 | |
| SCHEMBL4284826 | 0.72 | KMT2A (0.48) | CDC7METIDO1TDO2CYP19A1 | |
| SCHEMBL4291497 | 0.70 | GRM2 (0.39) | CDC7IDO1CYP19A1SLC9A1GRM2 | |
| SCHEMBL3673146 | 0.70 | CDC7 (0.49) | CDC7TDO2GRM2 | |
| SCHEMBL3671856 | 0.69 | KDM4E (0.37) | IDO1TDO2HPGD | |
| SCHEMBL16241084 | 0.69 | CYP19A1 (0.35) | CDC7MAP4K4PRKACAGSK3BCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |