Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 5/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293011 | 0.92 | KDM4E (0.42) | KDM4EALDH1A1HPGDRECQLCASP3 | |
| SCHEMBL4291497 | 0.76 | GRM2 (0.39) | KDM4EALDH1A1HPGDIDO1MEN1 | |
| SCHEMBL4292592 | 0.71 | GRM2 (0.41) | KDM4EALDH1A1HPGDIDO1TSHR | |
| SCHEMBL4292554 | 0.70 | CDC7 (0.44) | HPGDIDO1TDO2 | |
| SCHEMBL4289574 | 0.70 | CDC7 (0.45) | KDM4E | |
| SCHEMBL3671620 | 0.69 | CDC7 (0.39) | HPGDIDO1TDO2 | |
| SCHEMBL3669940 | 0.69 | CYP19A1 (0.48) | ALDH1A1IDO1TDO2TSHR | |
| SCHEMBL4284874 | 0.69 | CDC7 (0.46) | KDM4EBCHE | |
| SCHEMBL3667322 | 0.67 | ROCK2 (0.43) | KDM4EALDH1A1HPGDIDO1 | |
| SCHEMBL4291234 | 0.66 | SMN1; SMN2 (0.51) | ALDH1A1HPGDTSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |