Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyrimethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 6/20 | 0.73 |
| ▸ | HEXB | P07686 | 6/20 | 0.73 |
| ▸ | DHFR | P00374 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | HTR2A | P28223 | 1/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.73 |
| ▸ | HTR2B | P41595 | 1/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimethamine SCHEMBL7201956 | 0.92 | HEXA (0.71) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL29381161 | 0.85 | HEXA (1.00) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL25129 | 0.85 | HEXA (1.00) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL15516970 | 0.85 | HEXA (1.00) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL30439479 | 0.85 | HEXA (0.81) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL21382838 | 0.85 | HEXA (0.81) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL11709944 | 0.84 | HEXA (0.97) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL28347069 | 0.84 | HEXA (0.97) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL8086889 | 0.84 | HEXA (0.97) | HEXAHEXBDHFRMEN1KMT2A | |
| Pyrimethamine SCHEMBL28861797 | 0.84 | HEXA (0.97) | HEXAHEXBDHFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120150151-A | Micro-grid group scheduling method and system based on load source uncertainty | 广东工业大学 | 2025-06-13 | — | — | CN | claimed |
| CN-119918989-A | Comprehensive service system and method for electricity quality of electricity demand side | 广东电网有限责任公司佛山供电局 | 2025-05-02 | — | — | CN | claimed |
| CN-118409410-A | Optical system, optical lens and electronic equipment | 深圳迈塔兰斯科技有限公司 | 2024-07-30 | — | — | CN | claimed |
| CN-116500653-A | Method for determining original observed quantity precision of satellite-borne GNSS receiver | 北京遥测技术研究所 | 2023-07-28 | — | — | CN | claimed |
| CN-112543506-B | Resource determination method and device | 大唐移动通信设备有限公司 | 2022-06-21 | — | — | CN | claimed |
| US-20250295729-A1 | NOVEL THERAPEUTIC METHODS OF USING PEPTIDOGLYCAN MUROPEPTIDES TO PROMOTE ATP SYNTHASE ACTIVITY AND MITOCHONDRIAL HOMEOSTASIS AND DEVELOPMENT | UNIV COLORADO REGENTS (US) | 2025-09-25 | — | — | US | disclosed |
| CN-120150151-A | Micro-grid group scheduling method and system based on load source uncertainty | 广东工业大学 | 2025-06-13 | — | — | CN | disclosed |
| CN-222838271-U | Far infrared optical system and far infrared optical lens | 深圳迈塔兰斯科技有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-222838271-U | Far infrared optical system and far infrared optical lens | 深圳迈塔兰斯科技有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-119918989-A | Comprehensive service system and method for electricity quality of electricity demand side | 广东电网有限责任公司佛山供电局 | 2025-05-02 | — | — | CN | disclosed |
| CN-119868350-A | Application of Galectin-3 inhibitor TD139 in treating tuberculous granuloma | 三峡大学 | 2025-04-25 | — | — | CN | disclosed |
| CN-119827187-A | Low-power consumption air heat exchanger performance test bed | 北京科荣达航空科技股份有限公司 | 2025-04-15 | — | — | CN | disclosed |
| CN-113755160-B | Stress mitochondria localization imaging probe composition and application thereof | 厦门大学 | 2023-05-09 | — | — | CN | disclosed |
| WO-2023019100-A2 | NOVEL THERAPEUTIC METHODS OF USING PEPTIDOGLYCAN MUROPEPTIDES TO PROMOTE ATP SYNTHASE ACTIVITY AND MITOCHONDRIAL HOMEOSTASIS AND DEVELOPMENT | THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) | 2023-02-16 | — | — | WO | disclosed |
| CN-114841186-A | Radio frequency identification method and reader | 深圳盈达信息科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-114839607-A | MFR waveform unit extraction method based on step-by-step variable threshold isolated forest | 中国人民解放军战略支援部队信息工程大学 | 2022-08-02 | — | — | CN | disclosed |
| CN-112543506-B | Resource determination method and device | 大唐移动通信设备有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-114616911-A | Information indication method and device | 华为技术有限公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-114553377-A | Method and apparatus in a node used for wireless communication | 上海朗帛通信技术有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-1399414-B1 | SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA | PARATEK PHARM INNC (US) | 2010-01-13 | — | — | EP | disclosed |