Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921930 | 0.96 | MCL1 (0.40) | MCL1ALDH1A1KDM4EHPGDGALR3 | |
| SCHEMBL3665293 | 0.77 | MCL1 (0.39) | MCL1ALDH1A1KDM4EHPGDGALR3 | |
| SCHEMBL3672345 | 0.75 | KDM4E (0.43) | MCL1ALDH1A1KDM4EHPGDGALR3 | |
| SCHEMBL2763451 | 0.74 | MCL1 (0.36) | MCL1ALDH1A1KDM4EHPGDGALR3 | |
| SCHEMBL3681528 | 0.73 | MCL1 (0.46) | MCL1ALDH1A1KDM4EHPGDGALR3 | |
| SCHEMBL3676539 | 0.73 | MCL1 (0.43) | MCL1ALDH1A1KDM4EHPGDGALR3 | |
| SCHEMBL6686812 | 0.73 | GRIA1 (0.47) | MCL1ALDH1A1KDM4EHPGDGALR3 | |
| SCHEMBL2923277 | 0.71 | HTT (0.36) | ALDH1A1KDM4EGAAPARP1ATM | |
| SCHEMBL3667719 | 0.70 | HTT (0.49) | MCL1ALDH1A1KDM4EHPGDGALR3 | |
| SCHEMBL6695728 | 0.70 | MCL1 (0.45) | MCL1ALDH1A1KDM4EHPGDGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164488-A1 | AMPA RECEPTOR ANTAGONISTS AND ALDOSE REDUCTASE INHIBITORS FOR NEUROPATHIC PAIN | Eisai R&D Management Co., Ltd. (JP) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009011410-A1 | AMPA RECEPTOR ANTAGONISTS AND ALDOSE REDUCTASE INHIBITORS FOR NEUROPATHIC PAIN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-22 | — | — | WO | disclosed |