Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3676539 | 0.81 | MCL1 (0.43) | KDM4EMCL1ALDH1A1HPGDADORA2A | |
| SCHEMBL2921930 | 0.80 | MCL1 (0.40) | KDM4EPIM1MCL1ALDH1A1HPGD | |
| SCHEMBL3681528 | 0.79 | MCL1 (0.46) | KDM4EMCL1ALDH1A1HPGDADORA2A | |
| SCHEMBL3665293 | 0.79 | MCL1 (0.39) | KDM4EPIM1MCL1ALDH1A1HPGD | |
| SCHEMBL6695728 | 0.78 | MCL1 (0.45) | KDM4EMCL1ALDH1A1HPGDGALR3 | |
| SCHEMBL6695575 | 0.76 | KDM4E (0.51) | KDM4EMCL1ALDH1A1HPGDADORA2A | |
| Water SCHEMBL4777584 | 0.76 | GRIA1 (0.47) | KDM4EMCL1ALDH1A1HPGDGALR3 | |
| SCHEMBL3667719 | 0.76 | HTT (0.49) | KDM4EMCL1ALDH1A1HPGDADORA2A | |
| SCHEMBL2918049 | 0.76 | GRIA1 (0.47) | KDM4EMCL1ALDH1A1HPGDGALR3 | |
| SCHEMBL6693263 | 0.76 | MCL1 (0.40) | KDM4EMCL1ALDH1A1HPGDGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164487-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR NEUROPATHIC PAIN | Eisai R&D Management Co., Ltd. (JP) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009011411-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR NEUROPATHIC PAIN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-22 | — | — | WO | disclosed |