Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.65 |
| ▸ | JAK3 | P52333 | 13/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338534 | 1.00 | JAK2 (0.65) | JAK2JAK3NTRK1KCNH2 | |
| SCHEMBL4980198 | 0.82 | JAK2 (0.64) | JAK2JAK3 | |
| SCHEMBL4421973 | 0.81 | JAK2 (0.54) | JAK2JAK3NTRK1KCNH2 | |
| SCHEMBL2160844 | 0.81 | JAK2 (0.54) | JAK2JAK3NTRK1KCNH2 | |
| SCHEMBL2332818 | 0.80 | JAK2 (0.65) | JAK2JAK3NTRK1KCNH2 | |
| SCHEMBL13494464 | 0.80 | JAK2 (0.67) | JAK2JAK3NTRK1 | |
| SCHEMBL3008423 | 0.79 | JAK2 (1.00) | JAK2JAK3KCNH2 | |
| SCHEMBL220017 | 0.78 | JAK3 (0.88) | JAK2JAK3NTRK1 | |
| SCHEMBL2161854 | 0.77 | JAK2 (0.54) | JAK2JAK3NTRK1KCNH2 | |
| SCHEMBL4419211 | 0.77 | JAK2 (0.54) | JAK2JAK3NTRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152702-A1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008135786-A1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |