Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.64 |
| ▸ | JAK3 | P52333 | 15/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972207 | 0.86 | JAK2 (0.64) | JAK2JAK3 | |
| SCHEMBL14675794 | 0.86 | JAK2 (0.64) | JAK2JAK3 | |
| SCHEMBL4969755 | 0.83 | JAK2 (0.50) | JAK2JAK3SMN1; SMN2 | |
| SCHEMBL4972280 | 0.83 | JAK2 (0.60) | JAK2JAK3 | |
| SCHEMBL3671795 | 0.82 | JAK2 (0.65) | JAK2JAK3 | |
| SCHEMBL2338534 | 0.82 | JAK2 (0.65) | JAK2JAK3 | |
| SCHEMBL4972221 | 0.82 | JAK2 (0.61) | JAK2JAK3KDM4ESMN1; SMN2 | |
| SCHEMBL4969772 | 0.81 | JAK2 (0.48) | JAK2JAK3KDM4ESMN1; SMN2 | |
| SCHEMBL2160844 | 0.79 | JAK2 (0.54) | JAK2JAK3 | |
| SCHEMBL4421973 | 0.79 | JAK2 (0.54) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |