SCHEMBL3672023

SCHEMBL3672023

O=C(O)C(=Cc1ccccc1)C(Cl)Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.50
AKR1C1 Q04828 1/20 0.48
MCL1 Q07820 1/20 0.47
CYP2C9 P11712 2/20 0.44
CYP3A4 P08684 1/20 0.44
TP53 P04637 1/20 0.42
ALDH1A1 P00352 4/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
MAPT P10636 3/20 0.42
HTT P42858 2/20 0.42
KDM4E B2RXH2 2/20 0.42
HPGD P15428 2/20 0.42
LMNA P02545 2/20 0.42
POLB P06746 1/20 0.42
MAPK1 P28482 1/20 0.42
FBP1 P09467 1/20 0.41
TSHR P16473 1/20 0.41
RECQL P46063 2/20 0.39
HDAC3 O15379 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1563519 0.81 AKR1C3 (0.52) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL3226792 0.79 AKR1C3 (0.55) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL689448 0.79 AKR1C3 (0.55) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL563697 0.79 AKR1C3 (0.50) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL22634102 0.79 AKR1C3 (0.55) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL27808245 0.78 AKR1C3 (0.48) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL9854466 0.75 AKR1C3 (0.50) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL563363 0.75 AKR1C3 (0.46) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL28419365 0.75 AKR1C3 (0.50) AKR1C3AKR1C1MCL1CYP2C9CYP3A4
SCHEMBL15968199 0.75 CYP1A2 (0.58) CYP2C9ALDH1A1MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9527997-B2 Polyorganosiloxane-containing graft copolymer, resin composition, and molded article MITSUBISHI RAYON CO., LTD. (JP) 2016-12-27 US disclosed
US-20160053040-A1 REINFORCING AGENT FOR POLYCARBONATE RESIN, POLYCARBONATE RESIN COMPOSITION, AND MOLDED ARTICLE MITSUBISHI CHEMICAL CORPORATION (JP) 2016-02-25 US disclosed
US-20150267048-A1 Polyorganosiloxane-Containing Graft Copolymer, Resin Composition, and Molded Article MITSUBISHI RAYON CO., LTD. (JP) 2015-09-24 US disclosed
US-8729205-B2 Flowability improver for engineering plastics, thermoplastic resin compositions containing the same and molded articles of the compositions MITSUBISHI RAYON CO., LTD. (JP) 2014-05-20 US disclosed
US-8202943-B2 Fluidity-improving agent, aromatic polycarbonate resin composition, and shaped article thereof MITSUBISHI RAYON CO., LTD. (JP) 2012-06-19 US disclosed
US-20100029855-A1 FLUIDITY-IMPROVING AGENT, AROMATIC POLYCARBONATE RESIN COMPOSITION, AND SHAPED ARTICLE THEREOF MITSUBISHI RAYON CO., LTD (JP) 2010-02-04 US disclosed