Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KRAS | P01116 | 2/20 | 0.45 |
| ▸ | SPR | P35270 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164607 | 0.88 | MAPT (0.61) | KMT2AMAPTKRASSPRPOLB | |
| SCHEMBL8187452 | 0.79 | SPR (0.54) | KMT2AMAPTKRASSPRPOLB | |
| SCHEMBL942032 | 0.78 | KMT2A (0.53) | KMT2AMAPTKRASSPRPOLB | |
| SCHEMBL20339425 | 0.68 | PARP1 (0.59) | KMT2AMAPTKRASSPRPOLB | |
| SCHEMBL18248461 | 0.67 | KMT2A (0.58) | KMT2AMAPTKRASSPRPOLB | |
| SCHEMBL654124 | 0.67 | DYRK1A (0.59) | KMT2AMAPTKRASSPRALDH1A1 | |
| SCHEMBL655888 | 0.67 | KMT2A (0.63) | KMT2AMAPTKRASSPRKDM4E | |
| SCHEMBL19090050 | 0.67 | KMT2A (0.58) | KMT2AMAPTKRASSPRPOLB | |
| SCHEMBL20668043 | 0.67 | KMT2A (0.58) | KMT2AMAPTKRASSPRKDM4E | |
| SCHEMBL16179032 | 0.67 | KMT2A (0.54) | KMT2AMAPTKRASSPRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170843-A1 | HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008149191-A1 | HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2008-12-11 | — | — | WO | disclosed |