Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 17/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3682613 | 1.00 | PTGER4 (0.37) | PTGER4PTGER3PTGER2TSHRUSP2 | |
| SCHEMBL3676019 | 0.85 | PTGER4 (0.38) | PTGER4PTGER3PTGER2 | |
| SCHEMBL6683752 | 0.84 | PTGER4 (0.42) | PTGER4PTGER3PTGER2TSHRUSP2 | |
| SCHEMBL24644852 | 0.83 | PTGER4 (0.44) | PTGER4PTGER3PTGER2 | |
| SCHEMBL3675753 | 0.82 | PTGER4 (0.35) | PTGER4PTGER3PTGER2TSHRUSP2 | |
| SCHEMBL1555462 | 0.79 | PTGER4 (0.40) | PTGER4PTGER3PTGER2 | |
| SCHEMBL4293753 | 0.77 | PTGER4 (0.38) | PTGER4PTGER3PTGER2TSHRUSP2 | |
| SCHEMBL3674649 | 0.76 | PTGER4 (0.54) | PTGER4PTGER3PTGER2 | |
| SCHEMBL3680513 | 0.76 | GAA (0.38) | PTGER4PTGER3TSHRUSP2 | |
| SCHEMBL11024464 | 0.76 | PTGER4 (0.54) | PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513589-B1 | 1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA LTD (CA) | 2010-11-10 | — | — | EP | claimed |