Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.68 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670946 | 0.82 | CRHR1 (0.64) | CRHR1MAOB | |
| SCHEMBL3748976 | 0.81 | CRHR1 (0.90) | CRHR1MAOB | |
| SCHEMBL3750761 | 0.81 | CRHR1 (1.00) | CRHR1MAOB | |
| SCHEMBL3756151 | 0.80 | CRHR1 (0.85) | CRHR1 | |
| SCHEMBL3754443 | 0.79 | CRHR1 (1.00) | CRHR1MAOB | |
| SCHEMBL4097723 | 0.79 | CRHR1 (0.73) | CRHR1 | |
| SCHEMBL13763756 | 0.79 | CRHR1 (0.80) | CRHR1MAOB | |
| SCHEMBL3752749 | 0.79 | CRHR1 (0.80) | CRHR1MAOB | |
| SCHEMBL3746202 | 0.79 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL3765127 | 0.79 | CRHR1 (1.00) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |