Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.35 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3337446 | 0.92 | EZH2 (0.37) | ROCK2ROCK1EZH2CYP1A2CYP3A4 | |
| SCHEMBL3338976 | 0.92 | EZH2 (0.38) | ROCK2ROCK1EZH2CYP1A2CYP3A4 | |
| SCHEMBL3340713 | 0.87 | ROCK2 (0.43) | ROCK2ROCK1P2RX7PDE4BPDE11A | |
| SCHEMBL3337190 | 0.84 | ROCK2 (0.37) | ROCK2ROCK1EZH2P2RX7PDE4B | |
| SCHEMBL3337468 | 0.84 | GPBAR1 (0.33) | CYP1A2CYP3A4CYP2D6CYP2C9HPGD | |
| SCHEMBL30509037 | 0.84 | GPBAR1 (0.33) | CYP1A2CYP3A4CYP2D6CYP2C9HPGD | |
| SCHEMBL3338822 | 0.83 | EZH2 (0.38) | ROCK2ROCK1EZH2CYP1A2CYP3A4 | |
| SCHEMBL3337521 | 0.81 | EZH2 (0.39) | ROCK2ROCK1EZH2P2RX7EED | |
| SCHEMBL3336661 | 0.81 | HPGD (0.41) | HPGDPPARDPPARA | |
| SCHEMBL3343027 | 0.81 | HPGD (0.41) | HPGDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155194-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008124610-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-10-16 | — | — | WO | disclosed |