Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 17/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3672639 | 0.90 | DGAT1 (0.78) | DGAT1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3671468 | 0.89 | DGAT1 (0.80) | DGAT1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3673344 | 0.89 | DGAT1 (0.76) | DGAT1MEN1NPC1RAB9AKMT2A | |
| Bicarbonate SCHEMBL15655199 | 0.89 | DGAT1 (0.76) | DGAT1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL603709 | 0.88 | DGAT1 (0.78) | DGAT1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL602580 | 0.88 | DGAT1 (0.78) | DGAT1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL603355 | 0.87 | DGAT1 (1.00) | DGAT1 | |
| SCHEMBL602953 | 0.87 | DGAT1 (1.00) | DGAT1 | |
| SCHEMBL602952 | 0.87 | DGAT1 (1.00) | DGAT1 | |
| SCHEMBL601101 | 0.85 | DGAT1 (1.00) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | claimed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | claimed |
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | disclosed |