Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphine SCHEMBL27852307 | 0.82 | — | — | |
| Phosphine SCHEMBL27866322 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL105888 | 0.82 | — | — | |
| Phosphine SCHEMBL542123 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL2776542 | 0.67 | — | — | |
| Ammonia Solution, Strong SCHEMBL5873257 | 0.67 | — | — | |
| Phosphine SCHEMBL595812 | 0.67 | — | — | |
| Water SCHEMBL21359897 | 0.67 | — | — | |
| Water SCHEMBL21404301 | 0.67 | — | — | |
| Phosphine SCHEMBL4382169 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904424-B1 | THE USE OF A PHOSPHORUS CONTAINING LIGAND AND A CYCLIC ORGANIC LIGAND IN A TRANSITION METAL COMPOUND | UMICORE AG & CO KG (DE) | 2014-12-10 | — | — | EP | disclosed |
| US-7671224-B2 | Use of a phosphorus containing ligand and a cyclic organic ligand in a transition metal compound | UMICORE AG & CO. KG (DE) | 2010-03-02 | — | — | US | disclosed |
| US-20080221345-A1 | Use of a Phosphorus Containing Ligand and a Cyclic Organic Ligand in a Transition Metal Compound | UMICORE AG & CO KG (DE) | 2008-09-11 | — | — | US | disclosed |