Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GBA1 | P04062 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390423 | 0.86 | ABCG2 (0.74) | ABCG2ALOX15SMN1; SMN2SLC2A1MAPK1 | |
| SCHEMBL389903 | 0.83 | MEN1 (0.74) | ABCG2ALOX15SMN1; SMN2NPSR1NPC1 | |
| SCHEMBL390057 | 0.80 | ABCG2 (0.80) | ABCG2ALOX15SMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL5486371 | 0.73 | ABCG2 (0.78) | ABCG2SLC2A1NPSR1NPC1RAB9A | |
| SCHEMBL387105 | 0.72 | SMN1; SMN2 (0.73) | ABCG2ALOX15SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4217675 | 0.71 | NPSR1 (1.00) | ALOX15SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL13692629 | 0.71 | SLC2A1 (1.00) | SMN1; SMN2SLC2A1TSHRHSD17B10ALDH1A1 | |
| SCHEMBL21670532 | 0.71 | ACP1 (0.51) | SMN1; SMN2SLC2A1NPSR1NPC1RAB9A | |
| SCHEMBL18764364 | 0.71 | MEN1 (0.79) | ABCG2ALOX15SMN1; SMN2SLC2A1MAPK1 | |
| SCHEMBL2412362 | 0.70 | MAPT (0.60) | ALOX15SMN1; SMN2TSHRMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100285494-A1 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |