SCHEMBL3673427

SCHEMBL3673427

CCCCc1nc2c(N)nc3ccccc3c2n1CCCOC(N)=O.Cc1ccc(S(=O)(=O)Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.59
TLR8 Q9NR97 4/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1960130 0.90 TLR7 (0.70) TLR7TLR8
SCHEMBL3671420 0.88 TLR7 (0.63) TLR7TLR8
SCHEMBL29034534 0.87 TLR7 (0.71) TLR7TLR8
SCHEMBL3970553 0.80 TLR7 (0.63) TLR7TLR8
SCHEMBL13721793 0.79 TLR7 (0.65) TLR7TLR8
SCHEMBL3970742 0.79 TLR7 (0.62) TLR7TLR8
SCHEMBL12003054 0.79 TLR8 (0.68) TLR7TLR8
SCHEMBL5746646 0.78 TLR7 (0.57) TLR7TLR8
SCHEMBL5616930 0.78 TLR7 (0.77) TLR7TLR8
SCHEMBL13613808 0.78 TLR7 (0.53) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2155743-A1 IMIDAZOQUINOLINES WITH IMMUNO-MODULATING PROPERTIES AstraZeneca AB (SE) 2010-02-24 EP disclosed
WO-2008135791-A1 IMIDAZOQUINOLINES WITH IMMUNO-MODULATING PROPERTIES ASTRAZENECA AB (SE) 2008-11-13 WO disclosed