Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 16/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CNR2 | P34972 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.60 |
| ▸ | MMP2 | P08253 | 5/20 | 0.59 |
| ▸ | MMP10 | P09238 | 5/20 | 0.59 |
| ▸ | MMP8 | P22894 | 5/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 3/20 | 0.56 |
| ▸ | MMP12 | P39900 | 3/20 | 0.56 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | MMP14 | P50281 | 2/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | MMP7 | P09237 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27683269 | 0.88 | MMP13 (0.67) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4932534 | 0.88 | MMP13 (0.67) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4930061 | 0.88 | MMP13 (0.65) | MMP13POLBMMP2MMP10MMP8 | |
| SCHEMBL4935082 | 0.87 | MMP13 (0.71) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4934699 | 0.86 | MMP13 (0.65) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4935263 | 0.86 | MMP13 (0.65) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4932584 | 0.86 | MMP13 (0.65) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL3668214 | 0.85 | MMP13 (0.56) | MMP13MMP2MMP10MMP8MMP3 | |
| Hydrochloric Acid SCHEMBL4937275 | 0.85 | MMP13 (0.64) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4935876 | 0.84 | MMP13 (0.74) | MMP13MMP2MMP10MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170843-A1 | HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-04-07 | — | — | EP | claimed |
| WO-2008149191-A1 | HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2008-12-11 | — | — | WO | claimed |