Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | USP8 | P40818 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30201734 | 1.00 | MAPK1 (0.47) | MAPK1MAP2K4MAPKAPK2MAPK6MAP2K1 | |
| SCHEMBL19115758 | 0.80 | MAP2K1 (0.38) | MAPK1MAP2K4MAPKAPK2MAPK6MAP2K1 | |
| SCHEMBL25206592 | 0.79 | MAP2K1 (0.47) | MAPK1MAP2K1PDPK1GAAMET | |
| SCHEMBL16252835 | 0.79 | MAP2K1 (0.47) | MAPK1MAP2K1LRRK2PDPK1GPR84 | |
| SCHEMBL8404437 | 0.75 | MAPK1 (0.54) | MAPK1MAP2K4MAPKAPK2MAPK6MAP2K1 | |
| SCHEMBL24857862 | 0.74 | USP8 (0.32) | MAPK1MAP2K4MAPKAPK2MAPK6USP8 | |
| SCHEMBL26096218 | 0.74 | MAP2K1 (0.36) | MAP2K1LRRK2ERBB2KDRFLT3 | |
| SCHEMBL19115902 | 0.73 | ERBB2 (0.35) | MAPK1MAP2K1ERBB2GRM5 | |
| SCHEMBL19104234 | 0.73 | ERBB2 (0.34) | MAPK1MAP2K4MAPKAPK2MAPK6MAP2K1 | |
| SCHEMBL5748255 | 0.73 | MET (0.43) | MAPK1USP8GAAMETTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3732210-A1 | COMPOSITION INCLUDING MULTIPLE TERMINALLY FUNCTIONALIZED POLYMERS | Bridgestone Corporation (JP) | 2020-11-04 | — | — | EP | disclosed |
| EP-2203482-A1 | POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC NITRILE COMPOUNDS | Bridgestone Corporation (JP) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009051700-A1 | POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC NITRILE COMPOUNDS | BRIDGESTONE CORPORATION (US) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009051702-A1 | POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC NITRILE COMPOUNDS | BRIDGESTONE CORPORATION (JP) | 2009-04-23 | — | — | WO | disclosed |