Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057658 | 0.82 | MEN1 (0.63) | MEN1KMT2ARAB9ANPC1CYP2D6 | |
| SCHEMBL3674393 | 0.82 | RAB9A (0.51) | MEN1KMT2ARAB9ANPC1CYP2D6 | |
| SCHEMBL17949767 | 0.81 | BRAF (0.53) | MEN1KMT2AHSD11B1MGLLBRAF | |
| SCHEMBL27810241 | 0.81 | MAPT (0.36) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL2925097 | 0.79 | MEN1 (0.49) | MEN1KMT2ARAB9ANPC1CYP2D6 | |
| SCHEMBL31085462 | 0.78 | MEN1 (0.44) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL104864 | 0.78 | SRD5A2 (0.55) | MEN1KMT2ASRD5A2ALDH1A1 | |
| SCHEMBL307335 | 0.78 | EPHX2 (0.44) | MEN1KMT2ARAB9ASRD5A2MAPT | |
| SCHEMBL1502290 | 0.77 | MEN1 (0.51) | MEN1KMT2ARAB9ANPC1CYP2D6 | |
| SCHEMBL2762846 | 0.77 | MEN1 (0.51) | MEN1KMT2ARAB9ANPC1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157811-A | Class dependent inference based on machine learning | 国际商业机器公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-109071438-B | Process for preparing fexofenadine and intermediates used therein | 赛诺菲-安万特德国有限公司 | 2023-02-21 | — | — | CN | disclosed |
| CN-107428678-B | Process for the preparation of 2- [4- (cyclopropanecarbonyl) phenyl ] -2-methyl-propionitrile | 赛诺菲-安万特德国有限公司 | 2021-01-01 | — | — | CN | disclosed |
| CN-107428678-B | Process for the preparation of 2- [4- (cyclopropanecarbonyl) phenyl ] -2-methyl-propionitrile | 赛诺菲-安万特德国有限公司 | 2021-01-01 | — | — | CN | disclosed |
| CN-107428678-B | Process for the preparation of 2- [4- (cyclopropanecarbonyl) phenyl ] -2-methyl-propionitrile | 赛诺菲-安万特德国有限公司 | 2021-01-01 | — | — | CN | disclosed |
| US-10696633-B2 | Process for the preparation of fexofenadine and of intermediates used therein | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2020-06-30 | — | — | US | disclosed |
| US-10696633-B2 | Process for the preparation of fexofenadine and of intermediates used therein | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2020-06-30 | — | — | US | disclosed |
| EP-3365327-B1 | PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN | SANOFI AVENTIS DEUTSCHLAND (DE) | 2019-11-20 | — | — | EP | disclosed |
| EP-3365327-B1 | PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN | SANOFI AVENTIS DEUTSCHLAND (DE) | 2019-11-20 | — | — | EP | disclosed |
| US-10336698-B2 | Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2019-07-02 | — | — | US | disclosed |
| US-20010021791-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. | 2001-09-13 | — | — | US | disclosed |
| US-20010020114-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. | 2001-09-06 | — | — | US | disclosed |
| US-20010018521-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. | 2001-08-30 | — | — | US | disclosed |
| US-6242606-B1 | REACTING A A,A-DIMETHYLPHENYLACETIC ACID AMIDE WITH A W-HALO COMPOUND PRODUCES W'-HALO-A-KETO-A,A-DIMETHYLPHENYLACETIC ACID AMIDE AND REACTING IT WITH A PIPERIDINE COMPOUND; 2-(4-(4-CHLORO-BUTYRYL)-PHENYL)-2-METHY-PROPIONIC ACID | MERRELL PHARMACEUTICALS INC. | 2001-06-05 | — | — | US | disclosed |
| US-20010000038-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | CHATTEM INC. | 2001-03-15 | — | — | US | disclosed |
| CN-1274711-A | New intermediate for preparation of anti-histamine piperidine derivatives | MERRELL DOW PHARMA (US) | 2000-11-29 | — | — | CN | disclosed |
| US-6147216-A | Intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 2000-11-14 | — | — | US | disclosed |
| CN-1128987-A | Novel intermediates for the preparation of antihistaminic piperidine derivatives | MERRELL DOW PHARMA (US) | 1996-08-14 | — | — | CN | disclosed |
| EP-0705245-A1 | NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000480-A1 | NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1995-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000038-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | MEN1 2722/4885KMT2A 1588/4885RAB9A 2426/4885 |
| US-20010020114-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | MEN1 2716/4885KMT2A 2070/4885RAB9A 1845/4885 |
| US-10336698-B2 | Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile | CYP4B1, CYP3A4, CYP4F2 | MEN1 2615/4885KMT2A 1437/4885RAB9A 3549/4885 |
| US-20010021791-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | MEN1 2111/4885KMT2A 2014/4885RAB9A 2472/4885 |
| US-20010018521-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | MEN1 2708/4885KMT2A 2055/4885RAB9A 2272/4885 |
| US-10696633-B2 | Process for the preparation of fexofenadine and of intermediates used therein | CYP4F2, CYP4F3, NISCH | MEN1 2626/4885KMT2A 2418/4885RAB9A 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.