Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.63 |
| ▸ | IKBKB | O14920 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053472 | 0.90 | IKBKB (0.66) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL5898693 | 0.88 | JAK2 (0.61) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL5898697 | 0.86 | JAK2 (0.59) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL13269939 | 0.85 | JAK2 (0.62) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL13116577 | 0.82 | JAK2 (0.51) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL3508176 | 0.79 | IKBKB (0.62) | JAK2IKBKBJAK3MEN1KMT2A | |
| SCHEMBL6312507 | 0.78 | NPC1 (0.49) | JAK2IKBKBJAK3CHEK1 | |
| SCHEMBL5898673 | 0.78 | JAK2 (0.64) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL3510299 | 0.78 | JAK2 (1.00) | JAK2JAK3KCNH2 | |
| SCHEMBL4082755 | 0.76 | IKBKB (0.69) | JAK2IKBKBJAK3MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |