Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.66 |
| ▸ | JAK2 | O60674 | 5/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673734 | 0.90 | JAK2 (0.63) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL5898693 | 0.89 | JAK2 (0.61) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL5898697 | 0.87 | JAK2 (0.59) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL4082755 | 0.85 | IKBKB (0.69) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL10051836 | 0.84 | IKBKB (0.68) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL1683039 | 0.81 | IKBKB (0.63) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL1929619 | 0.81 | IKBKB (0.63) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL1681706 | 0.81 | IKBKB (0.67) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL13116577 | 0.81 | JAK2 (0.51) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL7055208 | 0.81 | IKBKB (0.75) | IKBKBJAK2JAK3MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |