⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019150 | 0.76 | — | — | |
| SCHEMBL1484476 | 0.76 | — | — | |
| SCHEMBL9018986 | 0.76 | — | — | |
| SCHEMBL22533514 | 0.72 | — | — | |
| SCHEMBL30624284 | 0.69 | — | — | |
| SCHEMBL13971386 | 0.69 | — | — | |
| SCHEMBL11760828 | 0.69 | — | — | |
| SCHEMBL300026 | 0.69 | — | — | |
| SCHEMBL3731262 | 0.67 | — | — | |
| SCHEMBL9106 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017051353-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017051354-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-30 | — | — | WO | disclosed |
| EP-1807436-B1 | HETEROBIFUNCTIONAL POLY(ETHYLENE GLYCOL) AND USES THEREOF | INTEZYNE TECHNOLOGIES INC (US) | 2014-06-18 | — | — | EP | disclosed |
| US-20130102604-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-8354443-B2 | Cyclopropane indolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-01-15 | — | — | US | disclosed |
| WO-2011069298-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |
| US-20110144106-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | US | disclosed |
| WO-2011070039-A1 | SPIRO INDOLE - CYCLOPROPANE INDOLINONES USEFUL AS AMPK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |
| US-7728152-B2 | Process for producing 2-benzoyloxyacetaldehyde derivative | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2010-06-01 | — | — | US | disclosed |
| US-7692033-B2 | Process for producing 2-benzoyloxyacetaldehyde derivative | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2010-04-06 | — | — | US | disclosed |
| US-20050234246-A1 | Process for producing 2-benzoyloxyacetaldehyde derivative | DAICEL CHEMICAL INDUSTRIES, LTD. | 2005-10-20 | — | — | US | disclosed |
| US-20030139600-A1 | 2-pyridylsilane, processes for producing and using the same | SUMITOMO CHEMICAL CO., LTD. | 2003-07-24 | — | — | US | disclosed |
| US-6548673-B1 | Alkylation using transition metal complex catalyst; purified by acid/base extraction | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-04-15 | — | — | US | disclosed |
| US-6531602-B2 | Desilylation of a 2-pyridylsilane to form an alcohol | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-03-11 | — | — | US | disclosed |
| US-20020165397-A1 | 2-Pyridylsilane, processes for producing and using the same | SUMITOMO CHEMICAL CO., LTD. | 2002-11-07 | — | — | US | disclosed |
| EP-1035125-A2 | 2-Pyridylsilane, processes for producing and using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-09-13 | — | — | EP | disclosed |
| EP-0404694-A2 | 4-hydroxy-8-methoxy-2-methyl-6, 7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline, and process for preparing the same | MITSUBISHI KASEI CORPORATION (JP) | 1990-12-27 | — | — | EP | disclosed |
| EP-0387156-A2 | A process for preparing cotarnine | MITSUBISHI KASEI CORPORATION (JP) | 1990-09-12 | — | — | EP | disclosed |
| US-4769480-A | Benzylamine derivative | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1988-09-06 | — | — | US | disclosed |
| EP-0214051-A2 | Benzylamine derivative | MITSUBISHI KASEI CORPORATION (JP) | 1987-03-11 | — | — | EP | disclosed |